Tyler Robbins Fitness

B.Sc. Biochemistry, Certified Strength and Conditioning Specialist (CSCS), Certified CrossFit Trainer (CCFT/CF-L3), USA Weightlifting Level 1

Filtering by Tag: Exercise DNA methylation

Dads with "Dad Bods" make fat kids

How's that for a title?

I have been wanting to write about this topic since it caught my attention back in December, but have just not had the time to get to it until now.

I am absolutely fascinated by the field of epigenetics, or more specifically, the study of epigenetics that looks at genetic markers passed down from one generation to the next. In other words, the lifestyle you lead may end up being forwarded to your children if you are in stage of your life when you are wishing to conceive.

Take this study, for example from Cell Metabolism:

It is not entirely known what all of these genetic markers mean, but it is clear that there are changes being made at a genetic level for individuals who have lost weight. Or, another way to look at it, children of obese fathers unfortunately run a greater risk of being obese themselves, for no other reason than because their fathers were overweight around the time of conception.

Up until now, it seemed quite likely that obese children become obese due to the lifestyle. If you grow up in a household where your parents are making poor nutritional decisions, or are inactive, then there is a greater likelihood that those personality traits will be passed on. Unfortunately this study tells us a more startling tale. Even if an individual wishes to change their lifestyle, they may have more of an uphill battle based on their parents' lifestyle choices.

This isn't all bad news, however, as I always say that information is power. Nobody gets to choose their parents, we just have to play the cards we are dealt. However, if you can find out more information about your parents' lifestyles at the time of your conception, you may have a better indication of how strict you need to be in order to maintain a healthy body weight, for example.

And, if you are an aspiring father, stop being so damn selfish and get your ass in shape so your kids don't have to start off their lives at a disadvantage!

Interesting stuff...





Exercise alters your DNA!

At times I need to remind myself that I have my B.Sc. in Biochemistry, and even though I have been out of university for a while now, that back corner of my brain can still think like a scientist.

I came across this research study online a little while ago, and I have been trying to wrap my head around it, deciphering the meaning of it and how amazingly profound it is.

 OK, so we all know that every single cell in our bodies has DNA. Remember that double-helix structure you learned back in biology class? Well, your DNA sequence is one thing that determines your "genes." Even though every cell in your body (except your sperm/eggs and immune cells) has the same chromosomes and the same DNA sequencing, they look and behave drastically different!
 
There are a whole list of cast and characters involved with how your DNA sequencing is "transcribed" into various functions and operations that your body uses for day-to-day operations. One of these factors is known as DNA methylation.
 
DNA methylation changes the expression of genes, usually decreasing it (the decrease in the expression of one gene might increase the expression of another). These so called epigenetic changes influence cell behavior, and are ultimately responsible for cell identity, i.e. it's what makes your skin cell different from your heart cell even though skin cells have the same DNA as heart cells, remember this stuff yet?

The researchers found that regular exercise for 6 months changed the methylation states of many genes in our fat (adipose) cells, including 31 genes specific to obesity and diabetes type 2, reducing their expression level a small but significant amount, <10%.

So why/how is this relevant?

This study has shown that our cells are identifying and changing based on extrinsic factors such as exercise. Not only is exercise making a ton of other 'good' things happening in your body, but it is apparently changing the way your cells function on the most basic level!

It is entirely possible for these changes to your DNA to be heritable. So, a healthy, active person could be giving their offspring a head-start with healthier genes. This is a double-edge sword of course, because not only could you be giving your child a slight genetic advantage by staying active, but the reverse could be true too and you could be setting them a step behind by being inactive.
 
One thing that should be noted about this study, and noted for potential future studies is how stable these changes are. Does one workout cause your DNA to methylate forever? For one day? For a week? We know that methylation is reversible, so maybe not exercising for a specific amount of time may reverse the positive effects, who knows!
  
There are a lot of important questions raised here, as with any worthwhile scientific study, but it is really exciting to think of the possibilities that this field of research is heading!